(S)--β-alanine benzyl ester

Base Information

• Chemical Name: (S)--β-alanine benzyl ester
• CAS No.: 155873-50-0
• Molecular Formula: C₃₀H₃₄N₂O₅
• Molecular Weight: 502.61
• Mol file: 155873-50-0.mol

Synonyms:(S)--β-alanine benzyl ester

Chemical Property of (S)--β-alanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)--β-alanine benzyl ester

There total 2 articles about (S)--β-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

β-alanine benzyl ester p-toluenesulfonate (27019-47-2) + N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine (119273-61-9,128779-47-5,147923-08-8) → (S)--β-alanine benzyl ester (155873-50-0) + 3-isobutoxycarbonylamino-propionic acid benzyl ester

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(99)01493-8

Reference yield: 93.0%

β-alanine benzyl ester p-toluenesulfonate (27019-47-2) + N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine (119273-61-9,128779-47-5,147923-08-8) → (S)--β-alanine benzyl ester (155873-50-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 19h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.08.064

Reference yield: 95.0%

(S)--β-alanine benzyl ester (155873-50-0) → L-4,4'-biphenylalanyl-β-alanine benzyl ester hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2011.08.064

upstream raw materials:

β-alanine benzyl ester p-toluenesulfonate

N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine

Downstream raw materials:

L-4,4'-biphenylalanyl-β-alanine benzyl ester formate

N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanyl-β-alanine benzyl ester

N-[1-(S)-carboxy-3-phenylpropyl]-L-4,4'-biphenylalanyl-β-alanine