{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester
CAS No.:917079-03-9
Molecular Formula:C₃₆H₃₈N₄O₄S
Molecular Weight:622.788
Hs Code.:

{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

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Chemical Property of {4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

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Technology Process of {4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

There total 9 articles about {4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875271-79-7
(2-phenylthiophen-3-yl)acetic acid methyl ester

: 917079-03-9
{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

3: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

4: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

5: 33 percent Turnov_. / CsF on Celite / acetonitrile / 48 h / Heating

6: 93 percent / hydrazine hydrate / methanol; tetrahydrofuran / 4.5 h / 20 °C

With copper(l) iodide; aluminium trichloride; hydrazine hydrate; diethylamine; cesium fluoride; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-86-6
(2-phenylthiophen-3-yl)acetic acid ethyl ester

: 917079-03-9
{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: KOH / methanol / 3 h / Heating

2: 3.3 g / HCl / 5 h / Heating

3: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

4: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

5: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

6: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

7: 33 percent Turnov_. / CsF on Celite / acetonitrile / 48 h / Heating

8: 93 percent / hydrazine hydrate / methanol; tetrahydrofuran / 4.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; copper(l) iodide; aluminium trichloride; hydrazine hydrate; diethylamine; cesium fluoride; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 136343-83-4
(E)-4-Chloro-3-formyl-4-phenyl-but-3-enoic acid ethyl ester

: 917079-03-9
{4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / tetrahydrofuran / 4 h / Heating

1.2: dimethylformamide / 18 h / 130 °C

2.1: KOH / methanol / 3 h / Heating

3.1: 3.3 g / HCl / 5 h / Heating

4.1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

5.1: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

6.1: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

7.1: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

8.1: 33 percent Turnov_. / CsF on Celite / acetonitrile / 48 h / Heating

9.1: 93 percent / hydrazine hydrate / methanol; tetrahydrofuran / 4.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; copper(l) iodide; aluminium trichloride; hydrazine hydrate; diethylamine; triethylamine; cesium fluoride; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 4.1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018