4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

Base Information

Chemical Name:4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid
CAS No.:1334785-55-5
Molecular Formula:C₃₁H₃₇N₃O₇
Molecular Weight:563.651
Hs Code.:

Synonyms:4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

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Chemical Property of 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

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Technology Process of 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

There total 5 articles about 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 1334785-40-8
ethyl 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-(benzamido)benzoate

: 1334785-55-5
4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

Guidance literature:: ethyl 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-(benzamido)benzoate; With potassium carbonate; In methanol; water; for 2h; Reflux;

With hydrogenchloride; In water; pH=7;
DOI:10.1016/j.ejmech.2011.06.011

Reference yield:

: 1235166-67-2
ethyl 4-(3-bromopropoxy)-3-nitrobenzoate

: 1334785-55-5
4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / water / pH Ca_. 11

1.2: 4 h / Reflux

2.1: hydrogenchloride; iron / ethanol; water / 1 h / Reflux

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: potassium carbonate / methanol; water / 2 h / Reflux

4.2: pH 7

With hydrogenchloride; iron; potassium carbonate; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.06.011

Reference yield:

: 1235166-70-7
ethyl 4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-nitrobenzoate

: 1334785-55-5
4-(3-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)propoxy)-3-benzamidobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; iron / ethanol; water / 1 h / Reflux

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: potassium carbonate / methanol; water / 2 h / Reflux

3.2: pH 7

With hydrogenchloride; iron; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.06.011