(E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate

Base Information

• Chemical Name: (E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate
• CAS No.: 1470004-89-7
• Molecular Formula: C₁₆H₂₀O₆
• Molecular Weight: 308.331
• Mol file: 1470004-89-7.mol

Synonyms:(E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate

Chemical Property of (E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate

There total 1 articles about (E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

dimethyl (4R)-4-(2-bromo-1-hydroxyethyl)-8-oxospiro[4.5]deca-6,9-diene-2,2-dicarboxylate → (E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate (1470004-89-7)

Guidance literature:

With azobisisobutyronitrile; tri-n-butyl-tin hydride; In toluene; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2017.07.003

Reference yield: 59.0%

(E)-dimethyl 2-(4-hydroxybenzyl)-2-(4-hydroxybut-2-en-1-yl)malonate (1470004-89-7) → C15H16O5 + dimethyl 6-hydroxy-4-vinyl-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate (1470004-60-4)

Guidance literature:

With triphenylmethyl perchlorate; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2013.09.042

Downstream raw materials:

dimethyl 6-hydroxy-4-vinyl-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate