N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine

Base Information

• Chemical Name: N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine
• CAS No.: 179747-01-4
• Molecular Formula: C₂₂H₃₆N₂O₇S
• Molecular Weight: 472.603

Synonyms:N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine

Chemical Property of N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine

Chemical Property:

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Technology Process of N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine

There total 3 articles about N₂-[(1,1-dimethylethoxy)carbonyl]-N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9) → N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N6-methyl-L-lysine (179747-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. CuCO₃*Cu(OH)2 / 19 h / Heating

1.2: NaHCO₃ / acetone / 18 h

2.1: 3.34 g / aq. NaOH / dioxane / 18 h / 0 °C / pH 10 - 11

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1021/jm0303857

Reference yield:

N6-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N6-methyl-L-lysine (179747-19-4) + di-tert-butyl dicarbonate (24424-99-5) → N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N6-methyl-L-lysine (179747-01-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 ℃; for 18h; pH=10 - 11;

DOI:10.1021/jm0303857

Reference yield:

Nε-methyllysine hydrochloride (7622-29-9) → N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N6-methyl-L-lysine (179747-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. CuCO₃*Cu(OH)2 / 19 h / Heating

1.2: NaHCO₃ / acetone / 18 h

2.1: 3.34 g / aq. NaOH / dioxane / 18 h / 0 °C / pH 10 - 11

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1021/jm0303857

upstream raw materials:

N₆-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-N₆-methyl-L-lysine

di-tert-butyl dicarbonate

N^ε-methyllysine hydrochloride

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

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