ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

Base Information

Chemical Name:ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate
CAS No.:121393-36-0
Molecular Formula:C₁₄H₁₉N₅O₂
Molecular Weight:289.337
Hs Code.:

Synonyms:ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

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Chemical Property of ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

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Technology Process of ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

There total 5 articles about ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121375-13-1
4-(4-amino-3-iodo-5-methylphenyl)-1,2,4-triazole

: 121393-36-0
ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Al₂O₃ / Pd(PPh₃)4 / toluene / 1) 75 deg C, 18 h, 2) reflux, 24 h

2: 12 percent / DIBAL / toluene; tetrahydrofuran / 2.5 h / Ambient temperature

3: toluene / 2.5 h / Heating

4: NaBH₃CN / ethanol / 10 h / Heating

With aluminum oxide; diisobutylaluminium hydride; sodium cyanoborohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00129a005

Reference yield:

: 102792-08-5
4-(4-Amino-3-methylphenyl)-1,2,4-triazole

: 121393-36-0
ethyl N-<<2-amino-3-methyl-5-(1,2,4-triazol-1-yl)phenyl>methyl>glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: 31 percent / ICl, NaOAc / acetic acid / 2 h / Ambient temperature

2: 92 percent / Al₂O₃ / Pd(PPh₃)4 / toluene / 1) 75 deg C, 18 h, 2) reflux, 24 h

3: 12 percent / DIBAL / toluene; tetrahydrofuran / 2.5 h / Ambient temperature

4: toluene / 2.5 h / Heating

5: NaBH₃CN / ethanol / 10 h / Heating

With aluminum oxide; sodium acetate; Iodine monochloride; diisobutylaluminium hydride; sodium cyanoborohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; acetic acid; toluene;
DOI:10.1021/jm00129a005