2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Base Information

• Chemical Name: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
• CAS No.: 302964-24-5
• Molecular Formula: C11H10ClN3OS
• Molecular Weight: 267.739
• Hs Code.: 29333990
• Mol file: 302964-24-5.mol

Synonyms:2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide;

Chemical Property of 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Chemical Property:

• Vapor Pressure: 1.99E-05mmHg at 25°C
• Melting Point: 208.0 to 212.0 °C
• Refractive Index: 1.714
• Boiling Point: 362 °C at 760 mmHg
• PKA: 11.09±0.70(Predicted)
• Flash Point: 172.7 °C
• PSA: 96.25000
• Density: 1.474 g/cm³
• LogP: 3.59360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

There total 19 articles about 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide + thiourea (17356-08-0) → 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide (302964-24-5)

Guidance literature:

N-(2-chloro-6-methylphenyl)-3-ethoxyprop-2-enamide; With 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(I) bromide; In tetrahydrofuran; for 0.5h;

thiourea; In tetrahydrofuran; at 40 ℃; for 1.5h; Temperature; Solvent; Reagent/catalyst;

Reference yield: 98.8%

(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide (863127-76-8) + thiourea (17356-08-0) → 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide (302964-24-5)

Guidance literature:

(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide; With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide; In tetrahydrofuran; at 40 ℃;

thiourea; In tetrahydrofuran; for 1.5h; Temperature; Concentration; Solvent; Reagent/catalyst;

Reference yield: 97.23%

C10H9BrClNO2 + thiourea (17356-08-0) → 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide (302964-24-5)

Guidance literature:

for 0.0611111h; Microwave irradiation;

upstream raw materials:

[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester

2-chloro-6-methylaniline

thiourea

(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide

Downstream raw materials:

2-(6-chloro-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide