C₂₁H₂₇F₃ClN₃O₂Si

Base Information

• Chemical Name: C₂₁H₂₇F₃ClN₃O₂Si
• CAS No.: 945469-40-9
• Molecular Formula: C₂₁H₂₇ClF₃N₃O₂Si
• Molecular Weight: 473.998
• Mol file: 945469-40-9.mol

Synonyms:C₂₁H₂₇F₃ClN₃O₂Si

Chemical Property of C₂₁H₂₇F₃ClN₃O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₇F₃ClN₃O₂Si

There total 17 articles about C₂₁H₂₇F₃ClN₃O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H29F3ClN3O3Si (945469-39-6) → C21H27F3ClN3O2Si (945469-40-9)

Guidance literature:

With potassium tert-butylate; p-toluenesulfonyl chloride; In tetrahydrofuran; at 20 - 60 ℃; for 5.5h;

DOI:10.1021/jm070312d

Reference yield:

(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester (496841-07-7) → C21H27F3ClN3O2Si (945469-40-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 72 percent / KOH / methanol / 2.42 h / 0 °C

2: i-Pr₂NEt / DMAP / CH₂Cl₂ / 48 h / 20 °C

3: LiBHEt₃ / tetrahydrofuran / -78 - 20 °C

4: 4-methylmorpholine N-oxide / n-Pr₄NRuO₄ / acetonitrile; CH₂Cl₂ / 4 h / 20 °C

5: 8 percent / CsF / 29 h / 20 - 50 °C

6: TFA / CH₂Cl₂ / 0.5 h / 20 °C

7: i-Pr₂NEt / CH₂Cl₂ / -78 - 20 °C

8: t-BuOK; p-toluenesulfonyl chloride / tetrahydrofuran / 5.5 h / 20 - 60 °C

With potassium hydroxide; potassium tert-butylate; lithium triethylborohydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; cesium fluoride; trifluoroacetic acid; dmap; tetrapropylammonium perruthennate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm070312d

Reference yield:

(2S,3R)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester (184046-77-3) → C21H27F3ClN3O2Si (945469-40-9)

Guidance literature:

Multi-step reaction with 6 steps

1: LiBHEt₃ / tetrahydrofuran / -78 - 20 °C

2: 4-methylmorpholine N-oxide / n-Pr₄NRuO₄ / acetonitrile; CH₂Cl₂ / 4 h / 20 °C

3: 8 percent / CsF / 29 h / 20 - 50 °C

4: TFA / CH₂Cl₂ / 0.5 h / 20 °C

5: i-Pr₂NEt / CH₂Cl₂ / -78 - 20 °C

6: t-BuOK; p-toluenesulfonyl chloride / tetrahydrofuran / 5.5 h / 20 - 60 °C

With potassium tert-butylate; lithium triethylborohydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; cesium fluoride; trifluoroacetic acid; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jm070312d

upstream raw materials:

C₂₁H₂₉F₃ClN₃O₃Si

(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester

4-amino-2-chloro-3-methyl-benzonitrile

2-chloro-4-isocyanato-3-methyl-benzonitrile