4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Base Information

Chemical Name:4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester
CAS No.:1123157-63-0
Molecular Formula:C₂₃H₃₅BrO₅
Molecular Weight:471.432
Hs Code.:

Synonyms:4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

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Chemical Property of 4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

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Technology Process of 4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

There total 17 articles about 4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 1123157-61-8
4-[2-(2-ethoxycarbonylethyl)-3-(6-hydroxyhexyl)phenoxy]butyric acid ethyl ester

: 1123157-63-0
4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 10 ℃; for 3h;

Reference yield:

: 4-[3-(6-bromohex-1-enyl)-2-(2-ethoxycarbonylvinyl)phenoxy]butyric acid ethyl ester

: 1123157-63-0
4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 40 ℃; for 20h; under 28443.9 Torr; Autoclave; Large scale;
DOI:10.1021/op300302s

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1123157-63-0
4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2: sodium ethanolate / ethanol / 48 h / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

With dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; ethanol; dichloromethane; water; ethyl acetate; chlorobenzene; acetonitrile; 2: Horner-Wadsworth-Emmons Olefination / 4: Wittig Reaction / 5: Wittig Reaction;