methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

Base Information

Chemical Name:methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate
CAS No.:1037835-12-3
Molecular Formula:C₂₂H₂₄FN₃O₄
Molecular Weight:413.449
Hs Code.:

Synonyms:methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

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Chemical Property of methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

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Technology Process of methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

There total 6 articles about methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1415560-32-5
3-(endo-amino)-8-(phenylmethyl)-8-azabicyclo[3.2.1]octane dihydrochloride

: 125568-71-0
methyl 2,4-difluoro-5-nitrobenzoate

: 1037835-12-3
methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 10h;

Reference yield:

: 100-46-9
benzylamine

: 1037835-12-3
methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / 1 h / 70 °C

1.2: 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

3.1: ethanol; sodium / 90 - 120 °C

3.2: 0 °C / pH 2

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 0 - 20 °C

With hydrogenchloride; ethanol; hydroxylamine hydrochloride; water; sodium acetate; sodium; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 1037835-12-3
methyl 4-[(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)amino]-2-fluoro-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / 1 h / 70 °C

1.2: 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

3.1: ethanol; sodium / 90 - 120 °C

3.2: 0 °C / pH 2

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 0 - 20 °C

With hydrogenchloride; ethanol; hydroxylamine hydrochloride; water; sodium acetate; sodium; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;