(E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester
• CAS No.: 361543-13-7
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 361543-13-7.mol

Synonyms:(E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester

Chemical Property of (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester

There total 4 articles about (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate (212051-35-9) → (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester (361543-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminum hydride / toluene / 0.75 h / -90 °C

2: CH₂Cl₂ / 1 h / Heating

With diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.tetlet.2005.05.004

Reference yield:

N-(4-methoxybenzyl)-2,2,2-trichloroacetamide (123558-64-5) → (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester (361543-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / CSA / CH₂Cl₂ / 18 h / 20 °C

2: diisobutylaluminum hydride / toluene / 0.75 h / -90 °C

3: CH₂Cl₂ / 1 h / Heating

With camphor-10-sulfonic acid; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.tetlet.2005.05.004

Reference yield:

(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal (160238-46-0) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-(S)-5-(4-Methoxy-benzyloxy)-4-methyl-pent-2-enoic acid ethyl ester (361543-13-7)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1016/j.tetlet.2005.05.004

upstream raw materials:

(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal

ethyl (triphenylphosphoranylidene)acetate

N-(4-methoxybenzyl)-2,2,2-trichloroacetamide

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

Downstream raw materials:

C₆₁H₉₄I₂O₁₁Si₂

C₆₁H₉₄ClIO₁₁Si₂

C₆₀H₉₂ClIO₁₂Si₂

2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide