(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

Base Information

• Chemical Name: (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol
• CAS No.: 129360-69-6
• Molecular Formula: C₂₁H₂₀F₂N₂O
• Molecular Weight: 354.399

Synonyms:(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

Chemical Property of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

Chemical Property:

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Technology Process of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

There total 2 articles about (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester (129359-41-7) → (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol (129360-69-6)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1021/jm00075a020

Reference yield:

4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole (129360-64-1) → (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol (129360-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / tetrahydrofuran / 65 h / Heating

2: 81 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00075a020

Reference yield: 75.0%

(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol (129360-69-6) → (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal (129360-72-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00075a020

upstream raw materials:

(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole

Downstream raw materials:

(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

(E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid (S)-1,1,2-triphenylethyl ester

(E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid, methyl ester

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