2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

Base Information

Chemical Name:2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine
CAS No.:131514-79-9
Molecular Formula:C₁₇H₂₁N₃
Molecular Weight:267.374
Hs Code.:

Synonyms:2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

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Chemical Property of 2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

Chemical Property:

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Technology Process of 2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

There total 6 articles about 2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126234-15-9
2,3,4,5-tetrahydro-3-methyl-9-nitro-4-(phenylmethyl)-1H-1,4-benzodiazepin-5-one

: 131514-79-9
2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

Guidance literature:: With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 24h;
DOI:10.1021/jm00106a040

Reference yield:

: 6286-36-8
2-bromo-3-nitrobenzoic acid chloride

: 131514-79-9
2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1 h / Heating

2: Na₂CO₃ / butan-1-ol / 1.5 h / Heating

3: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating

4: lithium aluminum hydride, conc. H₂SO₄ / tetrahydrofuran / 24 h

With 2-hydroxypyridin; lithium aluminium tetrahydride; sulfuric acid; sodium carbonate; In tetrahydrofuran; xylene; butan-1-ol;
DOI:10.1021/jm00106a040

Reference yield:

: 573-54-6
2-bromo-3-nitro-benzoic acid

: 131514-79-9
2,3,4,5-tetrahydro-3-methyl-4-(phenylmethyl)-1H-1,4-benzodiazepin-9-amine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / toluene / 2 h / Heating

2: 1 h / Heating

3: Na₂CO₃ / butan-1-ol / 1.5 h / Heating

4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating

5: lithium aluminum hydride, conc. H₂SO₄ / tetrahydrofuran / 24 h

With 2-hydroxypyridin; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; sodium carbonate; In tetrahydrofuran; toluene; xylene; butan-1-ol;
DOI:10.1021/jm00106a040