(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

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Chemical Name:(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid
CAS No.:80647-66-1
Molecular Formula:C₄₀H₄₈N₆O₈
Molecular Weight:740.857
Hs Code.:

(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

Synonyms:(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

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Chemical Property of (S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

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Technology Process of (S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

There total 5 articles about (S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 80647-64-9
Bpoc-Nle-Asn-Ala-Trp-OPh

: 80647-66-1
(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

Guidance literature:: With 2,3-dimercapto-succinic acid; dihydrogen peroxide; In water; N,N-dimethyl-formamide; for 0.5h;
DOI:10.1016/S0040-4020(01)98918-5

Reference yield:

: 74227-47-7
Z-Asn-Ala-OMe

: 80647-66-1
(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / hydrazine hydrate / dimethylformamide / 18 h / Ambient temperature

2: HCl, tert-butyl nitrite / dimethylformamide; dioxane / 0.17 h / -20 °C

3: TEA / dimethylformamide / 72 h / -10 °C

4: 96 percent / H₂, HCl / Pd/C / dimethylformamide / 3.5 h

5: 95 percent / NMM / dimethylformamide / 72 h / Ambient temperature

6: 80 percent / DMS, H₂O₂ / dimethylformamide; H₂O / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; tert.-butylnitrite; 2,3-dimercapto-succinic acid; TEA; hydrogen; dihydrogen peroxide; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)98918-5

Reference yield:

: [(S)-1-((S)-1-Azidocarbonyl-ethylcarbamoyl)-2-carbamoyl-ethyl]-carbamic acid benzyl ester

: 80647-66-1
(S)-2-((S)-2-{(S)-2-[(S)-2-(1-Biphenyl-4-yl-1-methyl-ethoxycarbonylamino)-hexanoylamino]-3-carbamoyl-propionylamino}-propionylamino)-3-(1H-indol-3-yl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: TEA / dimethylformamide / 72 h / -10 °C

2: 96 percent / H₂, HCl / Pd/C / dimethylformamide / 3.5 h

3: 95 percent / NMM / dimethylformamide / 72 h / Ambient temperature

4: 80 percent / DMS, H₂O₂ / dimethylformamide; H₂O / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; 2,3-dimercapto-succinic acid; TEA; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)98918-5