(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

Base Information

Chemical Name:(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine
CAS No.:1231956-52-7
Molecular Formula:C₁₇H₂₄ClF₃N₂
Molecular Weight:348.839
Hs Code.:

Synonyms:(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

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Chemical Property of (S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

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Technology Process of (S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

There total 4 articles about (S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1231958-24-9
(S)-tert-butyl 3-(4-chlorophenyl)-3-(2-(1,1,1-trifluoro-2-methylpropan-2-amine)ethyl)piperidine-1-carboxylate

: 1231956-52-7
(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

Guidance literature:: (S)-tert-butyl 3-(4-chlorophenyl)-3-(2-(1,1,1-trifluoro-2-methylpropan-2-amine)ethyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; at 18 - 25 ℃;

Reference yield:

: 1231958-22-7
(S)-tert-butyl 3-(4-chlorophenyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate

: 1231956-52-7
(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 0.33 h / 25 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18.5 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1231956-18-5
(S)-2-(3-(4-chlorophenyl)piperidin-3-yl)ethanol

: 1231956-52-7
(S)-N-(2-(3-(4-chlorophenyl)piperidin-3-yl)ethyl)-1,1,1-trifluoro-2-methylpropan-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 18 h / 25 °C / Inert atmosphere

2: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 0.33 h / 25 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18.5 h / 25 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;