(8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Chemical Name:(8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:1245747-93-6
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:(8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Chemical Property of (8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Technology Process of (8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

There total 1 articles about (8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245747-92-5
(R)-N-(4-methoxybenzyl)-2-(3-methylbut-2-en-1-yl)pyrrolidine-2-carboxamide

: 156-06-9
2-oxo-3-(phenyl)propionic acid

: 1245747-93-6
(8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: 2-oxo-3-(phenyl)propionic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

(R)-N-(4-methoxybenzyl)-2-(3-methylbut-2-en-1-yl)pyrrolidine-2-carboxamide; In tetrahydrofuran; for 48h; Reflux;
DOI:10.1016/j.tet.2010.04.093

Reference yield: 30.0%

: 1245747-93-6
(8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: (1R,7R,10R)-1-benzyl-2,8-diketo-9-(4-methoxybenzyl)-10-(1-methyl-ethenyl)-3,9-diazatricyclo[4.4.3.0]-undecane

Guidance literature:: (8aR)-3-benzyl-3-hydroxy-2-(4-methoxybenzyl)-8a-(3-methylbut-2-enyl)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃;

With triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2010.04.093