diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate
CAS No.:129175-57-1
Molecular Formula:C₃₀H₃₄N₄O₇
Molecular Weight:562.623
Hs Code.:

diethyl N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

Synonyms:diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

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Chemical Property of diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

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Technology Process of diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

There total 5 articles about diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 112888-91-2
(S)-2-(2-Methoxy-4-prop-2-ynylamino-benzoylamino)-pentanedioic acid diethyl ester

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 129175-57-1
diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm00173a026

Reference yield:

: 2597-56-0
4-nitro-o-anisic acid

: 129175-57-1
diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3 h

2: Et₃N / CH₂Cl₂ / 1 h

3: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

4: 58 percent / 2,6-lutidine / dimethylformamide / 9 h / 80 °C

5: 35 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

With 2,6-dimethylpyridine; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026

Reference yield:

: 39787-83-2
2-methoxy-4-nitrobenzoyl chloride

: 129175-57-1
diethyl N-<4--N-prop-2-ynylamino>-2-methoxybenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h

2: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

3: 58 percent / 2,6-lutidine / dimethylformamide / 9 h / 80 °C

4: 35 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

With 2,6-dimethylpyridine; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026