{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

Base Information

Chemical Name:{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride
CAS No.:1064700-79-3
Molecular Formula:C₂₇H₃₃ClN₄O₂*ClH
Molecular Weight:517.499
Hs Code.:

Synonyms:{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

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Chemical Property of {3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

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Technology Process of {3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

There total 7 articles about {3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1064701-90-1
{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine

: 1064700-79-3
{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; for 0.0333333h;

Reference yield:

: 58333-76-9
[4-(2-methoxy-phenyl)-piperidin-1-yl]-acetonitrile

: 1064700-79-3
{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3.78 h / 20 °C

1.2: 0 °C

2.1: ethanol / Heating / reflux

3.1: hydrogenchloride / diethyl ether / 0.03 h

With hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; ethanol;

Reference yield:

: 473706-98-8
1-(4-chloro-phenyl)-N-hydroxy-cyclobutanecarboxamidine

: 1064700-79-3
{3-[1-(4-chloro-phenyl)-cyclobutyl]-[1,2,4]oxadiazol-5-ylmethyl}-{2-[4-(2-methoxy-phenyl)-piperidin-1-yl]-ethyl}-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 0 - 20 °C

2: toluene / Heating / reflux

3: ethanol / Heating / reflux

4: hydrogenchloride / diethyl ether / 0.03 h

With hydrogenchloride; potassium carbonate; In diethyl ether; ethanol; acetone; toluene;