2,5-Dichlorothiophene-3-sulfonyl chloride

Base Information

• Chemical Name: 2,5-Dichlorothiophene-3-sulfonyl chloride
• CAS No.: 56946-83-9
• Molecular Formula: C4H Cl3 O2 S2
• Molecular Weight: 251.542
• Hs Code.: 2934999090
• European Community (EC) Number: 625-984-4
• DSSTox Substance ID: DTXSID20371123
• Nikkaji Number: J364.702A
• Wikidata: Q72468370
• Mol file: 56946-83-9.mol

Synonyms:2,5-Dichlorothiophene-3-sulfonyl chloride;56946-83-9;3-Thiophenesulfonyl chloride, 2,5-dichloro-;2,5-Dichlorothiophene-3-sulfonylchloride;2,5-DICHLOROTHIOPHENE-3-SULPHONYL CHLORIDE;2,5-dichloro-3-thiophenesulfonyl chloride;2,5-Dichlorothiophene-3-sulfonic acid chloride;C4HCl3O2S2;SCHEMBL388032;DTXSID20371123;MFCD00051665;AKOS000122858;2,5-dichloro-3-thienylsulfonyl chloride;2,5-dichlorothien-3-yl-sulfonyl chloride;AS-47765;BP-12195;2,5-dichloro-3-thiophene sulfone chloride;2,5-dichloro-3-thiophenesulfuryl chloride;3-thiophenesulfonyl chloride, 2,5-dichloro;2,5-dichloro-3-thiophene sulphonyl chloride;CS-0204634;FT-0610336;EN300-12412;F16070;2,5-bis(chloranyl)thiophene-3-sulfonyl chloride;2,5-Dichlorothiophene-3-sulfonyl chloride, 97%;A831249;Z119989850

Chemical Property of 2,5-Dichlorothiophene-3-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.000523mmHg at 25°C
• Melting Point: 130 °C
• Refractive Index: n20/D 1.595(lit.)
• Boiling Point: 256-257 ºC
• Flash Point: >110 ºC
• PSA: 70.76000
• Density: 1.697
• LogP: 4.06320
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 249.848355
• Heavy Atom Count: 11
• Complexity: 234

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dichlorothiophene-3-sulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=C1S(=O)(=O)Cl)Cl)Cl
• Uses: 2,5-Dichlorothiophene-3-sulfonyl chloride may be used in the preparation of:1-[(2,5-dichloro-3-thienyl)sulfonyl]-N-(6-nitro-1,3-benzothiazol-2-yl)piperidine-4-carboxamide6-chloro-3-isopropylamino-4H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide6-fluoro-3-methyl-4-(2,5-dichlorothiophene-3-sulfonyl)-3,4-dihydroquinoxalin-2-(1H)-one

Technology Process of 2,5-Dichlorothiophene-3-sulfonyl chloride

There total 4 articles about 2,5-Dichlorothiophene-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(benzylthio)-2,5-dichlorothiophene → 2,5-dichlorothiophene-3-sulfonyl chloride (56946-83-9)

Guidance literature:

With N-chloro-succinimide; water; acetic acid; at 20 ℃; for 1h;

Reference yield:

2,5-diclorothiophene (3172-52-9,173777-89-4) → 2,5-dichlorothiophene-3-sulfonyl chloride (56946-83-9)

Guidance literature:

With chlorosulfonic acid; thionyl chloride; for 2h; Ambient temperature;

DOI:10.1021/jm9607010

Reference yield:

→ 2,5-dichlorothiophene-3-sulfonyl chloride (56946-83-9)

Guidance literature:

1.6 Mol 2,5-Dichlorthiophen, 16.6 Mol Chlorsulfonsaeure, 1)-10grad 2)110-115grad (nicht rein erhalten; neben kleineren Mengen 2,5-Dichlor-thiophen-disulfonsaeure-dichlorid);

upstream raw materials:

2,5-diclorothiophene

Downstream raw materials:

2,5-dichloro-4-nitrothiophene-3-sulfonyl Chloride

1-(2,5-dichloro-thiophene-3-sulfonyl)-4-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]piperazine

4-{[(2,5-dichlorothiophen-3-yl)sulfonyl]amino}-2-hydroxybenzoic acid

4β-[2,5-dichlorothiophene-3-sulfonamido]podophyllotoxin