5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid

Base Information

• Chemical Name: 5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid
• CAS No.: 127949-54-6
• Molecular Formula: C₂₁H₂₁F₂NO₅
• Molecular Weight: 405.398
• Mol file: 127949-54-6.mol

Synonyms:5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid

Chemical Property of 5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid

There total 1 articles about 5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-Benzyl-3,3-difluoro-4-methyl-2-oxo-hex-5-enyl)-carbamic acid benzyl ester (127949-53-5) → 5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid (127949-54-6)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)77704-5

Reference yield: 80.0%

5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid (127949-54-6) → 5-Amino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid (127949-14-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; acetic acid; for 1h; under 2068.6 Torr;

DOI:10.1016/S0040-4039(00)77704-5

Reference yield:

5-Benzyloxycarbonylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid (127949-54-6) → 5-Acetylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid (140195-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂ / 10percent Pd/C / methanol; H₂O; acetic acid / 1 h / 2068.6 Torr

2: 90 percent / phosphate buffer (pH 6) / acetonitrile / 2 h / Ambient temperature

With phosphate buffer; hydrogen; palladium on activated charcoal; In methanol; water; acetic acid; acetonitrile;

DOI:10.1016/S0040-4039(00)77704-5

upstream raw materials:

(1-Benzyl-3,3-difluoro-4-methyl-2-oxo-hex-5-enyl)-carbamic acid benzyl ester

Downstream raw materials:

5-Amino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid

5-Acetylamino-3,3-difluoro-2-methyl-4-oxo-6-phenyl-hexanoic acid