1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

Base Information

Chemical Name:1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride
CAS No.:1372179-92-4
Molecular Formula:C₁₉H₁₈Cl₂N₄O₄*ClH
Molecular Weight:473.743
Hs Code.:

Synonyms:1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

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Chemical Property of 1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

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Technology Process of 1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

There total 13 articles about 1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1372186-94-1
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[2-oxo-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-1(2H)-yl]methyl}-1,4-oxazepane-4-carboxylate

: 1372179-92-4
1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 10 - 80 ℃; for 3.25h;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372179-92-4
1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.08 h / Cooling with ice

2.2: 0.5 h / 10 - 35 °C

2.3: 60 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 80 °C

3.2: 2 h / 70 °C

4.1: hydrogenchloride / ethanol / 3.25 h / 10 - 80 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1372186-92-9
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

: 1372179-92-4
1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.08 h / Cooling with ice

1.2: 0.5 h / 10 - 35 °C

1.3: 60 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 80 °C

2.2: 2 h / 70 °C

3.1: hydrogenchloride / ethanol / 3.25 h / 10 - 80 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;