4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile
CAS No.:1371608-33-1
Molecular Formula:C₁₄H₁₀F₆N₂O₂
Molecular Weight:352.236
Hs Code.:

Synonyms:4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

There total 6 articles about 4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₈F₆N₂O₂Si

: 1371608-33-1
4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1371608-34-2
4-((R)-2-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: With water; potassium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1371608-33-1
4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1371608-34-2
4-((R)-2-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 16 h / 0 - 20 °C

3: Dess-Martin periodane / dichloromethane / 6 h / 0 - 20 °C

4: cesium fluoride / tetrahydrofuran / 6 h / 0 °C

5: potassium hydroxide; water / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; water; caesium carbonate; Dess-Martin periodane; cesium fluoride; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1371608-33-1
4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1371608-34-2
4-((R)-2-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopentyl nitrite / acetonitrile / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 16 h / 0 - 20 °C

4.1: Dess-Martin periodane / dichloromethane / 6 h / 0 - 20 °C

5.1: cesium fluoride / tetrahydrofuran / 6 h / 0 °C

6.1: potassium hydroxide; water / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; water; caesium carbonate; Dess-Martin periodane; cesium fluoride; potassium hydroxide; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;