Cbz-GlyAib₈OH

Base Information

• Chemical Name: Cbz-GlyAib₈OH
• CAS No.: 1219615-83-4
• Molecular Formula: C₄₂H₆₇N₉O₁₂
• Molecular Weight: 890.047
• Mol file: 1219615-83-4.mol

Synonyms:Cbz-GlyAib₈OH

Chemical Property of Cbz-GlyAib₈OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-GlyAib₈OH

There total 6 articles about Cbz-GlyAib₈OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Cbz-GlyAib8OtBu (1219615-82-3) → Cbz-GlyAib8OH (1219615-83-4)

Guidance literature:

In trifluoroacetic acid; for 3h; Inert atmosphere;

DOI:10.1021/ja100662d

Reference yield:

N3(α-aminoisobutyric acid)4OtBu (1187839-02-6) → Cbz-GlyAib8OH (1219615-83-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; hydrogen / ethanol

2.1: acetic anhydride / 2 h / 120 °C

2.2: Reflux

3.1: palladium on activated charcoal; hydrogen / ethanol

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h

5.1: trifluoroacetic acid / dichloromethane

With palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1002/bip.21535

Reference yield:

N3Aib4-OH (1187839-35-5) → Cbz-GlyAib8OH (1219615-83-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride / 2 h / 120 °C

1.2: Reflux

2.1: palladium on activated charcoal; hydrogen / ethanol

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h

4.1: trifluoroacetic acid / dichloromethane

With palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1002/bip.21535

upstream raw materials:

Cbz-GlyAib₈OtBu

N₃(α-aminoisobutyric acid)₄OtBu

N₃Aib₄-OH

N₃Aib₈OtBu

Downstream raw materials:

Cbz-GlyAib₈PheNH₂

Cbz-GlyAib₈(L)-PheOMe

Cbz-GlyAib₈(D)-PheOMe