1-Boc-3-(amino)azetidine

Base Information

• Chemical Name: 1-Boc-3-(amino)azetidine
• CAS No.: 193269-78-2
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.227
• Hs Code.: 29339900
• European Community (EC) Number: 676-107-7
• DSSTox Substance ID: DTXSID30363973
• Nikkaji Number: J2.557.909G
• Wikidata: Q72447818
• Mol file: 193269-78-2.mol

Synonyms:193269-78-2;1-Boc-3-(amino)azetidine;1-Boc-3-aminoazetidine;tert-Butyl 3-aminoazetidine-1-carboxylate;3-Amino-1-N-Boc-azetidine;1-n-boc-3-aminoazetidine;MFCD01861753;1-Azetidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester;3-Amino-1-N-Boc azetidine;1-(tert-butoxycarbonyl)-3-aminoazetidine;1,1-dimethylethyl 3-aminoazetidine-1-carboxylate;TERT-BUTYL 3-AMINO-1-AZETIDINECARBOXYLATE;tert-butyl 3-aminoazetidinecarboxylate;tert-Butyl3-aminoazetidine-1-carboxylate;3-Amino-1-(tert-butoxycarbonyl)azetidine;3-amino-N-Boc-azetidine;3-Amino-1-Boc-azetidine;3-amino-1N-Boc-azetidine;1-N-Boc 3-amino azetidine;3-amino-1-(n-boc)azetidine;SCHEMBL121357;DTXSID30363973;3-amino-1-t-butoxycarbonylazetidine;BCP27505;BBL103086;STL556896;AKOS000189300;AC-2251;CS-W009078;PB17251;PS-5672;t-butyl 3-aminoazetidine-1-carboxylate;1-Boc-3-(amino)azetidine, AldrichCPR;SY005544;tert-butyl-3-aminoazetidine-1-carboxylate;tert-butyl 3-amino-1-azetidine-carboxylate;3-NITROPROPYL2-TETRAHYDROPYRANYLETHER;AM20090127;FT-0600394;EN300-79049;3-Aminoazetidine-1-carboxylic acid tert-butyl ester;Q-103133;3-amino-azetidine-1-carboxylic acid tert-butyl ester;F8880-7095;Z316174782

Chemical Property of 1-Boc-3-(amino)azetidine

Chemical Property:

• Vapor Pressure: 0.0468mmHg at 25°C
• Refractive Index: 1.495
• Boiling Point: 236.6 °C at 760 mmHg
• PKA: 8.29±0.20(Predicted)
• Flash Point: 96.9 °C
• PSA: 55.56000
• Density: 1.098 g/cm³
• LogP: 1.20260
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol, Water
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 172.121177757
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-3-aminoazetidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 34-51-22
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CC(C1)N

Technology Process of 1-Boc-3-(amino)azetidine

There total 11 articles about 1-Boc-3-(amino)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 3-aminoazetidine-1-carboxylic acid tert-butyl ester (193269-78-2)

Guidance literature:

Reference yield: 99.0%

tert-butyl 3-azidoazetidine-1-carboxylate (429672-02-6) → 3-aminoazetidine-1-carboxylic acid tert-butyl ester (193269-78-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 12h;

Reference yield:

tert-butyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-azetidinecarboxylate → 3-aminoazetidine-1-carboxylic acid tert-butyl ester (193269-78-2)

Guidance literature:

With methylamine; In methanol;

upstream raw materials:

tert-butyl 3-azidoazetidine-1-carboxylate

tert-butyl 3-hydroxyazetidine-1-carboxylate

di-tert-butyl dicarbonate

tert-butyl-3-iodoazetidine-1-carboxylate

Downstream raw materials:

tert-butyl 3-(4-benzylpiperazin-1-yl)azetidine-1-carboxylate

N-(tert-butyloxycarbonyl)-3-(2-nitrobenzenesulfonyl)aminoazetidine

tert-butyl 3-(2-(3-fluorophenyl)nicotinamido)azetidine-1-carboxylate

9-[4-(1-tert-Butoxycarbonylazetidin-3-yl)aminomethylbenzyl]-8-methoxy-2-(2-methoxyethoxy)adenine