2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Base Information

Chemical Name:2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester
CAS No.:176219-54-8
Molecular Formula:C₄₈H₆₄O₉Si
Molecular Weight:813.116
Hs Code.:

2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Synonyms:2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Suppliers and Price of 2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

There total 10 articles about 2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131380-48-8
(E)-4-(t-butyldiphenylsilyl)oxy-2-butenal

: 176219-54-8
2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 18-crown-6-ether, KN(SiMe₃)2 / 1.) THF, toluene, -78 deg C, 10 min, 2.) THF, toluene, 30 min

2: 69 percent / (i-Bu)2AlH/toluene / CH₂Cl₂ / 1 h / -78 °C

3: 86 percent / LiCl, MeSO₂Cl, collidine / dimethylformamide / 1.5 h / Ambient temperature

4: 1.) NaH / 1.) DMF, THF, 30 min, room t., 2.) DMF, THF, 3 h, room t.

With 2,3,5-trimethyl-pyridine; 18-crown-6 ether; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; methanesulfonyl chloride; toluene; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v96-017

Reference yield:

: 92808-78-1
(E)-4-(tert-butyldiphenylsilyloxy)-2-buten-1-ol

: 176219-54-8
2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 48 percent / PCC, NaOAc / tetrahydrofuran / 2 h / 25 °C

2: 1.) 18-crown-6-ether, KN(SiMe₃)2 / 1.) THF, toluene, -78 deg C, 10 min, 2.) THF, toluene, 30 min

3: 69 percent / (i-Bu)2AlH/toluene / CH₂Cl₂ / 1 h / -78 °C

4: 86 percent / LiCl, MeSO₂Cl, collidine / dimethylformamide / 1.5 h / Ambient temperature

5: 1.) NaH / 1.) DMF, THF, 30 min, room t., 2.) DMF, THF, 3 h, room t.

With 2,3,5-trimethyl-pyridine; 18-crown-6 ether; sodium acetate; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; methanesulfonyl chloride; toluene; pyridinium chlorochromate; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v96-017

Reference yield:

: 176219-52-6
(2Z,4E)-6-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dien-1-ol

: 176219-54-8
2-((E)-5-Benzoyloxy-2-methoxymethoxy-pent-2-enyl)-2-[(2Z,4E)-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexa-2,4-dienyl]-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / LiCl, MeSO₂Cl, collidine / dimethylformamide / 1.5 h / Ambient temperature

2: 1.) NaH / 1.) DMF, THF, 30 min, room t., 2.) DMF, THF, 3 h, room t.

With 2,3,5-trimethyl-pyridine; sodium hydride; methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide;
DOI:10.1139/v96-017