Technology Process of 3-(6,7-dimethoxyquinazolin-4-ylsulfanyl)-benzenamine
There total 7 articles about 3-(6,7-dimethoxyquinazolin-4-ylsulfanyl)-benzenamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-aminothiophenol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
6,7-dimethoxy-4-chloroquinazoline;
In
tetrahydrofuran;
at 20 ℃;
for 15h;
DOI:10.1021/jm2009925
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: nitric acid / 1 h / 20 - 25 °C
2.1: sodium hydroxide; potassium permanganate / 7 h
3.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 45 °C / High pressure
4.1: dimethyl sulfoxide / 140 - 170 °C
5.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux
6.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
6.2: 2 h / 80 - 85 °C
With
potassium permanganate; thionyl chloride; palladium on activated charcoal; potassium tert-butylate; hydrogen; nitric acid; sodium hydroxide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3390/molecules23010024
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; potassium permanganate / 7 h
2.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 45 °C / High pressure
3.1: dimethyl sulfoxide / 140 - 170 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux
5.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
5.2: 2 h / 80 - 85 °C
With
potassium permanganate; thionyl chloride; palladium on activated charcoal; potassium tert-butylate; hydrogen; sodium hydroxide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3390/molecules23010024
