2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Name:2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide
CAS No.:1428533-76-9
Molecular Formula:C₃₇H₃₃ClF₃N₇O₆S
Molecular Weight:796.227
Hs Code.:

Synonyms:2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Property of 2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Technology Process of 2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

There total 8 articles about 2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1428533-70-3
2-(2-(6-(3-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

: 1692-25-7
3-pyridylboronic acid

: 1428533-76-9
2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 120 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm301887f

Reference yield:

: 1428533-32-7
benzyl 2-(6-(3-bromobenzyl)-3,5-dichloro-2-oxopyrazin-1(2H)-yl)acetate

: 1428533-76-9
2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.67 h / Reflux

2: potassium carbonate; water / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

3: pyridine; trichlorophosphate / 2 h / -15 - 20 °C / Inert atmosphere

4: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water; ethanol / 0.25 h / 120 °C / Microwave irradiation

With pyridine; bis-triphenylphosphine-palladium(II) chloride; water; palladium diacetate; sodium carbonate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; water; acetonitrile; 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301887f

Reference yield:

: 109347-40-2
2-(3-bromophenyl)acetaldehyde

: 1428533-76-9
2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-(pyridin-3-yl)benzyl)pyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 0.02 h / 20 °C

1.2: 1 h / Reflux

2.1: hydrogenchloride / diethyl ether / 0.08 h

2.2: Reflux

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.67 h / Reflux

4.1: potassium carbonate; water / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

5.1: pyridine; trichlorophosphate / 2 h / -15 - 20 °C / Inert atmosphere

6.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water; ethanol / 0.25 h / 120 °C / Microwave irradiation

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; palladium diacetate; sodium carbonate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis / 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301887f