8,8-dimethyl-3-phenyl-2-thioxo-1,2,3,6,8,9-hexahydro-4H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidin-4-one

Base Information

Chemical Name:8,8-dimethyl-3-phenyl-2-thioxo-1,2,3,6,8,9-hexahydro-4H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidin-4-one
CAS No.:267665-49-6
Molecular Formula:C₁₈H₁₇N₃O₂S
Molecular Weight:339.418
Hs Code.:
Mol file:267665-49-6.mol

Synonyms:8,8-dimethyl-4-oxo-3-phenyl-2-thioxo-2,3,4,6,8,9-hexahydro-1H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidine

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Chemical Property of 8,8-dimethyl-3-phenyl-2-thioxo-1,2,3,6,8,9-hexahydro-4H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidin-4-one

Chemical Property:

Boiling Point:512.2±60.0 °C(Predicted)
PKA:-1.10±0.40(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 8,8-dimethyl-3-phenyl-2-thioxo-1,2,3,6,8,9-hexahydro-4H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidin-4-one

There total 3 articles about 8,8-dimethyl-3-phenyl-2-thioxo-1,2,3,6,8,9-hexahydro-4H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 103-72-0
phenyl isothiocyanate

: 267665-48-5
ethyl 2-amino-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carboxylate

: 267665-49-6
8,8-dimethyl-4-oxo-3-phenyl-2-thioxo-2,3,4,6,8,9-hexahydro-1H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: at 130 ℃; for 7h;
DOI:10.1007/BF02251803

Reference yield:

: 93956-88-8
2,2-dimethyl-4-(N-morpholino)-2,3-dihydro-6H-pyran

: 267665-49-6
8,8-dimethyl-4-oxo-3-phenyl-2-thioxo-2,3,4,6,8,9-hexahydro-1H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / tetrahydrofuran / 20 °C

2: 75 percent / NH₃ / tetrahydrofuran; H₂O / 6 h / 50 - 55 °C

3: 85.5 percent / 7 h / 130 °C

With ammonia; In tetrahydrofuran; water; 1: Condensation / 2: Cyclization / 3: Cycloaddition;
DOI:10.1007/BF02251803

Reference yield:

: 306740-23-8
ethyl 2-cyano-3-(2,2-dimethyl-4-morpholino-3,6-dihydro-2H-pyran-5-yl)acrylate

: 267665-49-6
8,8-dimethyl-4-oxo-3-phenyl-2-thioxo-2,3,4,6,8,9-hexahydro-1H-pyrano[3',4':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NH₃ / tetrahydrofuran; H₂O / 6 h / 50 - 55 °C

2: 85.5 percent / 7 h / 130 °C

With ammonia; In tetrahydrofuran; water; 1: Cyclization / 2: Cycloaddition;
DOI:10.1007/BF02251803