(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Base Information

Chemical Name:(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride
CAS No.:117942-52-6
Molecular Formula:C₁₀H₁₁NO₃*ClH
Molecular Weight:229.663
Hs Code.:

Synonyms:(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

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Chemical Property of (1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Chemical Property:

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Technology Process of (1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

There total 8 articles about (1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 117942-50-4
N-<<2-(trimethylsilyl)ethoxy>carbonyl>-O-<(2-methoxyethoxy)methyl>-(E)-2,3-methanotyrosine

: 117942-52-6
(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Guidance literature:: With hydrogenchloride; water; 3-methyl-phenol; In 1,4-dioxane; for 24h; Ambient temperature;
DOI:10.1021/jo00262a033

Reference yield:

: 117942-42-4
diethyl 4-<(2-methoxyethoxy)methoxy>benzalmalonate

: 117942-52-6
(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / dimethylsulfoxide; tetrahydrofuran / 1.) RT, 1 h, 2.) 50 deg C, 1 h

2: 78 percent / NaOH, H₂O / ethanol / 48 h / Ambient temperature

3: DPPA, Et₂N / toluene / 1 h / Heating

4: toluene / 20 h

5: 70 percent / NaOH, H₂O / ethanol / 1.) reflux, 2 h, 2.) RT, 20 h

6: 53 percent / HCl, H₂O, m-cresol / dioxane / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; water; 3-methyl-phenol; diethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00262a033

Reference yield:

: 117942-44-6
(Z)-1-(ethoxycarbonyl)-2-<4-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid

: 117942-52-6
(1S,2R)-1-Amino-2-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: DPPA, Et₂N / toluene / 1 h / Heating

2: toluene / 20 h

3: 70 percent / NaOH, H₂O / ethanol / 1.) reflux, 2 h, 2.) RT, 20 h

4: 53 percent / HCl, H₂O, m-cresol / dioxane / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; water; 3-methyl-phenol; diethylamine; In 1,4-dioxane; ethanol; toluene;
DOI:10.1021/jo00262a033