2-Amino-6-chloro-3-phenylpyridine

Base Information

• Chemical Name: 2-Amino-6-chloro-3-phenylpyridine
• CAS No.: 69214-19-3
• Molecular Formula: C11H9ClN2
• Molecular Weight: 204.659
• DSSTox Substance ID: DTXSID40355804
• Wikidata: Q72434759
• Mol file: 69214-19-3.mol

Synonyms:2-Amino-6-chloro-3-phenylpyridine;69214-19-3;6-chloro-3-phenylpyridin-2-amine;2-Pyridinamine,6-chloro-3-phenyl-;6-chloro-3-phenyl-2-pyridinamine;2-Pyridinamine, 6-chloro-3-phenyl-;SCHEMBL1901873;DTXSID40355804;AM1144;6-chloranyl-3-phenyl-pyridin-2-amine;AKOS015891749;AC-8788;FT-0611199;A836394

Chemical Property of 2-Amino-6-chloro-3-phenylpyridine

Chemical Property:

• Vapor Pressure: 3.25E-05mmHg at 25°C
• Melting Point: 155-157 °C
• Refractive Index: 1.635
• Boiling Point: 354.877 °C at 760 mmHg
• PKA: 2.20±0.50(Predicted)
• Flash Point: 168.424 °C
• PSA: 38.91000
• Density: 1.262 g/cm³
• LogP: 3.56540
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 204.0454260
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

99.0%Min ^*data from raw suppliers

2-Amino-6-chloro-3-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(C=C2)Cl)N

Technology Process of 2-Amino-6-chloro-3-phenylpyridine

There total 5 articles about 2-Amino-6-chloro-3-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(di-tert-butoxycarbonyl)amino-3-phenylpyridine 1-oxide → 6-chloro-3-phenyl-2-aminopyridine (69214-19-3)

Guidance literature:

With trichlorophosphate; In dichloromethane; at 35 ℃; for 16h;

Reference yield:

6-amino-5-phenyl-pyridin-2-ol (856965-78-1) → 6-chloro-3-phenyl-2-aminopyridine (69214-19-3)

Guidance literature:

With trichlorophosphate; at 170 - 175 ℃;

DOI:10.1039/jr9530003548

Reference yield:

6-amino-2-hydroxy-5-phenyl-nicotinonitrile (77609-05-3) → 6-chloro-3-phenyl-2-aminopyridine (69214-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated aqueous HBr; acetic acid

2: POCl₃ / 170 - 175 °C

With hydrogen bromide; acetic acid; trichlorophosphate;

DOI:10.1039/jr9530003548

upstream raw materials:

6-amino-5-phenyl-pyridin-2-ol

6-amino-2-hydroxy-5-phenyl-nicotinonitrile

3-methoxy-2-phenylacrylonitrile

3-isobutoxy-2-phenyl-acrylonitrile

Downstream raw materials:

2,6-diamino-3-phenylpyridine

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