1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Base Information

Chemical Name:1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil
CAS No.:129678-83-7
Molecular Formula:C₄₂H₄₉FN₂O₅Si₂
Molecular Weight:737.031
Hs Code.:

Synonyms:1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

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Chemical Property of 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

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Technology Process of 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

There total 3 articles about 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 129678-82-6
1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil

: 129678-83-7
1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00171a024

Reference yield:

: 129678-54-2
1-[(2R,3S,4S,5S)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-hydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

: 129678-83-7
1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / dimethylformamide / Ambient temperature

2: 64 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; diethylamino-sulfur trifluoride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a024

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 129678-83-7
1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / dimethylformamide / Ambient temperature

2: 64 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; diethylamino-sulfur trifluoride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a024