1-thio-beta-D-Galactopyranose sodium salt

Base Information

• Chemical Name: 1-thio-beta-D-Galactopyranose sodium salt
• CAS No.: 42891-22-5
• Molecular Formula: C6H11NaO5S
• Molecular Weight: 218.206
• Hs Code.: 29400090
• Mol file: 42891-22-5.mol

Synonyms:Sodium,(b-D-galactopyranosylthio)- (7CI);1-Thio-b-D-galactose sodium salt;

Chemical Property of 1-thio-beta-D-Galactopyranose sodium salt

Chemical Property:

• Melting Point: 145-150 °C dec.
• PSA: 115.45000
• LogP: -2.01620
• Storage Temp.: -20°C Freezer
• Solubility.: Water

Purity/Quality:

99.3% ^*data from raw suppliers

b-D-Thiogalactose sodium salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Thio-β-D-galactose Sodium Salt (cas# 42891-22-5) is a compound useful in organic synthesis.

Technology Process of 1-thio-beta-D-Galactopyranose sodium salt

There total 3 articles about 1-thio-beta-D-Galactopyranose sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3,4,6-tetra-O-acetyl-1S-acetyl-1-thio-β-D-galactopyranose (6806-56-0) → 1-thio-β-D-galactose (Na+-form) (42891-22-5)

Guidance literature:

With sodium methylate; In methanol; for 2h;

DOI:10.1039/c0ob01235a

Reference yield: 90.0%

2,3,4,6-tetra-O-acetyl-1-thio-D-galactopyranose (19879-84-6,56981-51-2,72541-16-3,72748-72-2,92691-83-3,110660-22-5,50615-66-2) → 1-thio-β-D-galactose (Na+-form) (42891-22-5)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 0.75h;

Reference yield:

2,3,4,6-tetra-O-acetyl-α/β-D-galactopyranose (3947-62-4,6207-76-7,10343-06-3,19235-21-3,22554-70-7,22860-22-6,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,47339-09-3) → 1-thio-β-D-galactose (Na+-form) (42891-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH, Molekularsieb 4 A / 1) CH₂Cl₂, 30 min, RT, 2) CH₂Cl₂, 2 h, RT

2: 90 percent / 0.25 M CH₃ONa / methanol / 4 h

With Molekularsieb 4 A; sodium methylate; sodium hydride; In methanol;

upstream raw materials:

2,3,4,6-tetra-O-acetyl-1S-acetyl-1-thio-β-D-galactopyranose

2,3,4,6-tetra-O-acetyl-α/β-D-galactopyranose

2,3,4,6-tetra-O-acetyl-1-thio-D-galactopyranose

Downstream raw materials:

1,3-bis(methanethiosulfonatomethyl)-5-thio-β-D-galactopyranosyldisulfanylmethyl-2,4,6-trimethyl-benzene

tris-(thio-β-D-galactopyranosyldisulfanylmethyl)-mesitylene

1,3-bis(5-thio-β-D-galactopyranosyldisulfanylmethyl)-5-methanethiosulfonatomethyl-2,4,6-trimethylbenzene

Refernces

• 1、 Wu, Bin,Yang, Xiaojian,Yan, Mingdi. "Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens". . p. 7751 - 7768. Retrieved 2019/09/10.
• 2、 Schmidt, Richard R.,Stumpp, Michael. "Glycosylimidates, 8. - Synthesis of 1-Thioglycosides". . p. 1249 - 1256. Retrieved 2007/10/02.