(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide
CAS No.:1419075-43-6
Molecular Formula:C₁₆H₂₁F₃N₂O₃
Molecular Weight:346.35
Hs Code.:

Synonyms:(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

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Chemical Property of (S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

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Technology Process of (S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

There total 10 articles about (S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1419075-42-5
(S)-benzyl [1-phenyl-2-(2-(2-(2,2,2-trifluoroacetamido)ethyl)-1,3-dioxan-2-yl)ethyl]carbamate

: 1419075-43-6
(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; for 3h; Reflux;
DOI:10.1002/ejoc.201200919

Reference yield:

: 1419075-37-8
(S)-benzyl [5-(1,3-dioxoisoindolin-2-yl)-3-oxo-1-phenylpentyl]carbamate

: 1419075-43-6
(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid; trimethyl orthoformate / dichloromethane / 18 h / 20 °C

2.1: hydrazine hydrate / methanol / 3 h / Reflux

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Reflux

With dmap; palladium 10% on activated carbon; ammonium formate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; trimethyl orthoformate; In methanol; dichloromethane;
DOI:10.1002/ejoc.201200919

Reference yield:

: 1419075-40-3
(S)-benzyl [2-(2-(2-aminoethyl)-1,3-dioxan-2-yl)-1-phenylethyl]carbamate

: 1419075-43-6
(S)-N-(2-(2-(2-amino-2-phenylethyl)-1,3-dioxan-2-yl)ethyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Reflux

With dmap; palladium 10% on activated carbon; ammonium formate; triethylamine; In methanol; dichloromethane;
DOI:10.1002/ejoc.201200919