7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

Base Information

Chemical Name:7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate
CAS No.:632329-25-0
Molecular Formula:C₅₂H₆₂N₄O₉
Molecular Weight:887.086
Hs Code.:

Synonyms:7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

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Chemical Property of 7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

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Technology Process of 7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

There total 8 articles about 7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 632329-24-9
C₆₅H₈₄N₄O₁₂SSi

: 632329-25-0
7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.5h; Heating;
DOI:10.1039/b209990j

Reference yield:

: 632329-23-8
C₆₂H₇₈N₄O₁₂SSi

: 632329-25-0
7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1039/b209990j

Reference yield:

: 634597-44-7
C₆₅H₈₂N₄O₁₂SSi

: 632329-25-0
7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: KBH₄; AcOH / 0.75 h / 20 °C

2: 77 percent / TBAF / tetrahydrofuran / 1.5 h / Heating

With potassium borohydride; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1039/b209990j