(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

Base Information

Chemical Name:(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid
CAS No.:1355052-30-0
Molecular Formula:C₂₂H₁₉FN₂O₄
Molecular Weight:394.402
Hs Code.:

Synonyms:(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

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Chemical Property of (S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

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Technology Process of (S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

There total 9 articles about (S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1355052-33-3
(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid methyl ester

: 1355052-30-0
(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

Guidance literature:: (S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4;

Reference yield:

: 2561-25-3
4-(4-fluorophenoxy)-1-nitrobenzene

: 1355052-30-0
(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

2.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

2.2: 0.5 h / 0 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / methanol / 3 h / 20 °C

5.2: pH 5

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

7.1: lithium hydroxide / tetrahydrofuran / 2 h / 0 °C

7.2: pH 4

With dmap; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; potassium acetate; sodium carbonate; dicyclohexyl-carbodiimide; lithium hydroxide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1355052-30-0
(S)-2-(2-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-acetylamino)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

3.2: 0.5 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / methanol / 3 h / 20 °C

6.2: pH 5

7.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

8.1: lithium hydroxide / tetrahydrofuran / 2 h / 0 °C

8.2: pH 4

With dmap; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; dicyclohexyl-carbodiimide; lithium hydroxide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;