7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide

Base Information

• Chemical Name: 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide
• CAS No.: 810661-19-9
• Molecular Formula: C₁₄H₁₀Cl₂N₂O₃S
• Molecular Weight: 357.217
• Mol file: 810661-19-9.mol

Synonyms:7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide

Chemical Property of 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide

There total 3 articles about 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H14Cl2N2O4S (1028289-90-8) → 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide (810661-19-9)

Guidance literature:

With sodium methylate; In methanol; at 40 ℃; for 2h;

DOI:10.1002/jhet.5570410516

Reference yield:

2-amino-4-chloro-benzoic acid methyl ester (5900-58-3) → 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide (810661-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 80 °C

2: MeONa / methanol / 2 h / 40 °C

With sodium methylate; triethylamine; In methanol; toluene;

DOI:10.1016/j.farmac.2005.05.009

Reference yield:

2-chlorobenzylsulfamoyl chloride (810661-22-4) → 7-chloro-3-(2-chlorobenzyl)-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide (810661-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 80 °C

2: MeONa / methanol / 2 h / 40 °C

With sodium methylate; triethylamine; In methanol; toluene;

DOI:10.1016/j.farmac.2005.05.009

upstream raw materials:

C₁₅H₁₄Cl₂N₂O₄S

2-amino-4-chloro-benzoic acid methyl ester

2-chlorobenzylsulfamoyl chloride