1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Base Information

Chemical Name:1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea
CAS No.:1376770-27-2
Molecular Formula:C₂₅H₂₀F₃N₅OS
Molecular Weight:495.528
Hs Code.:

Synonyms:1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Suppliers and Price of 1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

There total 5 articles about 1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1376770-17-0
6-(4-aminophenyl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine

: 2284-20-0
4-Methoxyphenyl isothiocyanate

: 1376770-27-2
1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

: 954221-91-1
4-chloro-6-(4-nitrophenyl)pyrimidine

: 1376770-27-2
1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

2: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

3: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1376770-27-2
1-(4-methoxyphenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 2 h / 80 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 120 °C / Microwave irradiation

3: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

4: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

5: tetrahydrofuran / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium acetate; palladium diacetate; sodium carbonate; tin(ll) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.03.092