(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

Base Information

Chemical Name:(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione
CAS No.:1350703-99-9
Molecular Formula:C₂₇H₂₆Cl₂O₄
Molecular Weight:485.407
Hs Code.:

Synonyms:(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

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Chemical Property of (E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

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Technology Process of (E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

There total 4 articles about (E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1350704-00-5
(E)-1-(4-bromobut-1-enyl)-2,4-dichlorobenzene

: 1350704-06-1
2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

: 1350703-99-9
(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

Guidance literature:: 2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

(E)-1-(4-bromobut-1-enyl)-2,4-dichlorobenzene; In N,N-dimethyl-formamide; at 20 ℃; for 96h; Inert atmosphere;
DOI:10.1021/ol2029367

Reference yield:

: 2-(5-phenylpent-4-yn-1-yl)malonic acid

: 1350703-99-9
(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 96 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol2029367

Reference yield:

: 57718-13-5
(5-bromo-pent-1-ynyl)-benzene

: 1350703-99-9
(E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 65 °C / Inert atmosphere

2.1: water; sodium hydroxide / methanol / Inert atmosphere

3.1: sulfuric acid / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 96 h / 20 °C / Inert atmosphere

With sulfuric acid; water; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol2029367