4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile

Base Information

• Chemical Name: 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile
• CAS No.: 773848-01-4
• Molecular Formula: C₂₆H₂₂N₄O₄
• Molecular Weight: 454.485

Synonyms:4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile

Chemical Property of 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile

Chemical Property:

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Technology Process of 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile

There total 6 articles about 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile (371765-91-2) + 2-bromomethyl-3'-methoxy-5-nitro-biphenyl → 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile (773848-01-4)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm030434f

Reference yield:

2-bromo-4-nitrotoluene (7745-93-9) → 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile (773848-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 12 h / Heating

2: NBS; benzoyl peroxide / CCl₄ / 48 h / Heating

3: Ag₂O / CH₂Cl₂ / 12 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; toluene; 1: Suzuki coupling;

DOI:10.1021/jm030434f

Reference yield:

3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile (773848-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 12 h / Heating

2: NBS; benzoyl peroxide / CCl₄ / 48 h / Heating

3: Ag₂O / CH₂Cl₂ / 12 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; toluene; 1: Suzuki coupling;

DOI:10.1021/jm030434f

upstream raw materials:

4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

2-bromo-4-nitrotoluene

3-methoxyphenylboronic acid

4-cyanobenzaldehyde

Downstream raw materials:

4-[(5-amino-3'-methoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile

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