{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

Base Information

Chemical Name:{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol
CAS No.:240415-18-3
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

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Chemical Property of {(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

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Technology Process of {(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

There total 8 articles about {(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 240133-69-1
(E)-(R)-7-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hept-2-en-1-ol

: 240415-18-3
{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; 4 A molecular sieve; In decane; dichloromethane; at -20 ℃; for 4h;
DOI:10.1021/ja000001r

Reference yield:

: 52813-63-5
(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone

: 240415-18-3
{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / TfOH / CH₂Cl₂; pentane / 30 h / 0 °C

2: DIBAL / toluene / 1 h / -78 °C

3: 2.04 g / benzene / 2 h / Heating

4: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C

5: 72 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

6: 86 percent / (-)-D-diethyl tartrate; Ti(O-i-Pr)4; tert-butylhydroperoxide / CH₂Cl₂; decane / 5 h / -23 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In decane; dichloromethane; N,N-dimethyl-formamide; toluene; pentane; benzene; 6: Sharpless asymmetric epoxidation;
DOI:10.1021/ol990648k

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 240415-18-3
{(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / TfOH / CH₂Cl₂; pentane / 30 h / 0 °C

2: DIBAL / toluene / 1 h / -78 °C

3: 2.04 g / benzene / 2 h / Heating

4: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C

5: 72 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

6: 86 percent / (-)-D-diethyl tartrate; Ti(O-i-Pr)4; tert-butylhydroperoxide / CH₂Cl₂; decane / 5 h / -23 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In decane; dichloromethane; N,N-dimethyl-formamide; toluene; pentane; benzene; 6: Sharpless asymmetric epoxidation;
DOI:10.1021/ol990648k