2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Base Information

Chemical Name:2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole
CAS No.:865689-06-1
Molecular Formula:C₂₉H₃₄N₂OSi
Molecular Weight:454.687
Hs Code.:

Synonyms:2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Chemical Property of 2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Technology Process of 2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

There total 4 articles about 2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 865689-04-9
2-(4-biphenyl)-4-bromo-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

: 63139-21-9
4-ethylphenylboronic acid

: 865689-06-1
2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene; for 16h; Heating;
DOI:10.3987/COM-05-10445

Reference yield:

: 865689-02-7
2-(4-biphenyl)-4,5-dibromo-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

: 865689-06-1
2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / n-BuLi; water / hexane; tetrahydrofuran / -78 - 20 °C

2: 78 percent / aq. potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; methanol / 16 h / Heating

With n-butyllithium; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; toluene; 2: Suzuki coupling;
DOI:10.3987/COM-05-10445

Reference yield:

: 5122-94-1
4-biphenylboronic acid

: 865689-06-1
2-(4-biphenyl)-4-(4-ethylphen yl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / aq. potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾ catalyst / toluene; methanol / 16 h / Heating

2: 45 percent / n-BuLi; water / hexane; tetrahydrofuran / -78 - 20 °C

3: 78 percent / aq. potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; methanol / 16 h / Heating

With n-butyllithium; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; toluene; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.3987/COM-05-10445