2-Amino-2-(pentafluorophenyl)ethan-1-ol

Base Information

Chemical Name:2-Amino-2-(pentafluorophenyl)ethan-1-ol
CAS No.:354153-48-3
Molecular Formula:C₈H₆F₅NO
Molecular Weight:227.134
Hs Code.:
DSSTox Substance ID:DTXSID201264392

Synonyms:354153-48-3;2-amino-2-(pentafluorophenyl)ethan-1-ol;DTXSID201264392;beta-Amino-2,3,4,5,6-pentafluorobenzeneethanol;EN300-1829177

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-2-(pentafluorophenyl)ethan-1-ol

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:227.03695463
Heavy Atom Count:15
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C(C(C1=C(C(=C(C(=C1F)F)F)F)F)N)O

Technology Process of 2-Amino-2-(pentafluorophenyl)ethan-1-ol

There total 2 articles about 2-Amino-2-(pentafluorophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 132505-34-1
(+/-)-1-(pentafluorophenyl)ethane-1,2-diol

: 354153-48-3
(+/-)-2-amino-2-(pentafluorophenyl)ethanol

Guidance literature:: With acetonitrile; for 3h; Heating;
DOI:10.1002/1099-0690(200105)2001:10<1937::aid-ejoc1937>3.3.co;2-u

Reference yield:

: 653-34-9,26838-55-1
2,3,4,5,6-pentafluorostyrene

: 354153-48-3
(+/-)-2-amino-2-(pentafluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / K₂OsO₂(OH)4; DABCO; K₂CO₃ / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 0 °C

2: 85 percent / CH₃CN; 98percent H₂SO₄ / 3 h / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; potassium dioxotetrahydroxoosmate(VI); potassium carbonate; acetonitrile; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; 2: Ritter rearrangement;
DOI:10.1002/1099-0690(200105)2001:10<1937::aid-ejoc1937>3.3.co;2-u