(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363478-92-5
Molecular Formula:C₃₂H₂₈N₄O₉S
Molecular Weight:644.662
Hs Code.:

Synonyms:(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Chemical Property of (7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Technology Process of (7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 19 articles about (7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 885227-03-2
5-(2-hydroxyethoxy)-1H-indole-2-carboxylic acid

: 1363481-42-8
(7-carbamoyl-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

: 1363478-92-5
(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1021/jm201717y

Reference yield:

: 869114-69-2
tert-butyl (6-cyanonaphthalen-2-yl)carbamate

: 1363478-92-5
(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 13 steps

1.1: N-iodo-succinimide; toluene-4-sulfonic acid / acetonitrile / 36 h / 35 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 16 h / 0 - 20 °C

3.1: tri-n-butyl-tin hydride / benzene / 20 °C / Reflux; Inert atmosphere

4.1: acetic acid; zinc / tetrahydrofuran; water / 2 h / Reflux

5.1: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

7.1: pyridine / 4 h / 0 °C

8.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

9.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

10.1: 1,4-dioxane / 24 h / Inert atmosphere; Reflux

11.1: triethylamine / dichloromethane / 0.33 h / 0 °C

12.1: trifluoroacetic acid / dichloromethane / 20 °C

13.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; dmap; N-iodo-succinimide; sulfuric acid; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil; benzene;
DOI:10.1021/jm201717y

Reference yield:

: C₁₄H₁₁IN₂

: 1363478-92-5
(7-carbamoyl-3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 2 h / 0 °C

2: acetic acid / 48 h / Reflux

3: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

4: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

5: 1,4-dioxane / 24 h / Inert atmosphere; Reflux

6: triethylamine / dichloromethane / 0.33 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 20 °C

8: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; sulfuric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm201717y