N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

Base Information

Chemical Name:N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide
CAS No.:1028458-64-1
Molecular Formula:C₂₅H₂₄FN₃O₃S
Molecular Weight:465.548
Hs Code.:

Synonyms:N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

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Chemical Property of N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

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Technology Process of N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

There total 5 articles about N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1028459-20-2
(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine

: 139631-62-2
cyclopropanesulfonyl chloride

: 1028458-64-1
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

Guidance literature:: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine; cyclopropanesulfonyl chloride; With pyridine; at 0 - 20 ℃; for 2.5h;

With triethylamine; at 20 ℃; for 18.5h;

Reference yield:

: 146137-76-0
2-Fluoro-5-iodo-benzaldehyde

: 1028458-64-1
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 20 - 150 °C

2: copper(l) iodide; caesium carbonate / 18 h / 120 °C / Inert atmosphere

3: triethylamine / dichloromethane

With copper(l) iodide; caesium carbonate; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2016.10.052

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 1028458-64-1
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; caesium carbonate / 18 h / 120 °C / Inert atmosphere

2: triethylamine / dichloromethane

With copper(l) iodide; caesium carbonate; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2016.10.052