6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

Base Information

Chemical Name:6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide
CAS No.:676631-56-4
Molecular Formula:C₂₁H₂₆ClN₃O₂
Molecular Weight:387.909
Hs Code.:

Synonyms:6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

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Chemical Property of 6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

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Technology Process of 6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

There total 5 articles about 6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 130290-79-8
4-tetrahydropyranmethylamine

: 676627-14-8
6-(3-chloro-phenylamino)-2-isopropyl-nicotinic acid hydrochloride

: 676631-56-4
6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

Guidance literature:: 6-(3-chloro-phenylamino)-2-isopropyl-nicotinic acid hydrochloride; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

4-tetrahydropyranmethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 4-(1-amino-2-methyl-propylidene)-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

: 676631-56-4
6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / ethanol / 28 h / Heating / reflux

2.1: O-phenyl phosphorodichloridate / 0.02 h / 170 °C / Microwave irradiation

3.1: 4 h / 120 °C

4.1: potassium hydroxide / ethanol / 4 h / Heating / reflux

4.2: pH 1

5.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

5.2: 20 °C

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; In ethanol; dichloromethane;

Reference yield:

: 676627-12-6
6-(3-chloro-phenylamino)-2-isopropyl-nicotinic acid ethyl ester

: 676631-56-4
6-(3-chloro-phenylamino)-2-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 4 h / Heating / reflux

1.2: pH 1

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2.2: 20 °C

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;