5-Chloropyridine-2-boronic acid

Base Information

• Chemical Name: 5-Chloropyridine-2-boronic acid
• CAS No.: 652148-91-9
• Molecular Formula: C5H5BClNO2
• Molecular Weight: 157.364
• Hs Code.: 2933399090
• Mol file: 652148-91-9.mol

Synonyms:Boronicacid, (5-chloro-2-pyridinyl)- (9CI);

Chemical Property of 5-Chloropyridine-2-boronic acid

Chemical Property:

• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.559
• Boiling Point: 317.694 °C at 760 mmHg
• PKA: 7.66±0.53(Predicted)
• Flash Point: 145.936 °C
• PSA: 53.35000
• Density: 1.415 g/cm³
• LogP: -0.58520
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloropyridine-2-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloropyridine-2-boronic acid was used as reagent in organic synthesis. Also used as phamaceutical Intermediates. Used in suzuki-Miyaura coupling processes.

Technology Process of 5-Chloropyridine-2-boronic acid

There total 1 articles about 5-Chloropyridine-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-Bromo-5-chloro-pyridine (40473-01-6) → (5-chloropyridin-2-yl)boronic acid (652148-91-9)

Guidance literature:

2-Bromo-5-chloro-pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

With Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.tet.2003.10.020

Reference yield: 72.0%

2?chloro?4-phenylbenzoquinazoline (4786-80-5) + (5-chloropyridin-2-yl)boronic acid (652148-91-9) → C23H14ClN3

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; toluene;

Reference yield: 70.0%

C24H24BBr3 + (5-chloropyridin-2-yl)boronic acid (652148-91-9) → C39H33BCl3N3

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 105 ℃; Inert atmosphere;

upstream raw materials:

2-Bromo-5-chloro-pyridine

Downstream raw materials:

5-chloro-2-phenylpyridine

5-(5-chloropyridin-2-yl)-N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]furan-2-carboxamide

2-({1-[4-(5-chloropyridin-2-yl)benzoyl]piperidin-4-yl}methyl)-4-methyl-N-(2,2,2-trifluoroethyl)-2H-indazole-5-carboxamide

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