C₃₂H₂₂N₃O₂P

Base Information

• Chemical Name: C₃₂H₂₂N₃O₂P
• CAS No.: 99582-51-1
• Molecular Formula: C₃₂H₂₂N₃O₂P
• Molecular Weight: 511.519
• Mol file: 99582-51-1.mol

Synonyms:C₃₂H₂₂N₃O₂P

Chemical Property of C₃₂H₂₂N₃O₂P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₂N₃O₂P

There total 10 articles about C₃₂H₂₂N₃O₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

triphenylphosphine (603-35-0) + 7-azido-2-(2'-pyridyl)quinoline-5,8-quinone (99573-24-7) → C32H22N3O2P (99582-51-1)

Guidance literature:

In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/jo00350a069

Reference yield:

2-acetylpyridine (1122-62-9) → C32H22N3O2P (99582-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / N-benzyltrimethylammonium hydroxide (Triton B) / tetrahydrofuran / 18 h / 25 °C

2: 98 percent / HBr / benzene / 7 h / 60 °C

3: 100 percent / Fremy's salt, aq. KH₂PO₄ / acetone / 1.5 h / 25 °C

4: 85 percent / aq. sodium azide / CH₂Cl₂ / 23 h / 25 °C

5: 51 percent / CH₂Cl₂ / 1 h / 25 °C

With potassium dihydrogenphosphate; sodium azide; potassiuim nitrosodisulfonate; hydrogen bromide; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; dichloromethane; acetone; benzene;

DOI:10.1021/jo00350a069

Reference yield:

methyl 4-bromo-2-nitro-3-hydroxybenzoate (37524-01-9) → C32H22N3O2P (99582-51-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) a) DMF, from 0 to 25 deg C, 0.5 h, b) 25 deg C, 20 h

2: 93 percent / LiBH₄ / tetrahydrofuran / 21 h / 25 °C

3: 82 percent / pyridinium dichromate / CH₂Cl₂ / 11 h / 25 °C

4: 93 percent / aq. Na₂S₂O₄ / tetrahydrofuran / 0.5 h / 60 °C

5: 90 percent / N-benzyltrimethylammonium hydroxide (Triton B) / tetrahydrofuran / 18 h / 25 °C

6: 98 percent / HBr / benzene / 7 h / 60 °C

7: 100 percent / Fremy's salt, aq. KH₂PO₄ / acetone / 1.5 h / 25 °C

8: 85 percent / aq. sodium azide / CH₂Cl₂ / 23 h / 25 °C

9: 51 percent / CH₂Cl₂ / 1 h / 25 °C

With potassium dihydrogenphosphate; dipyridinium dichromate; lithium borohydride; sodium azide; sodium dithionite; potassiuim nitrosodisulfonate; hydrogen bromide; N-benzyl-trimethylammonium hydroxide; sodium hydride; In tetrahydrofuran; dichloromethane; acetone; benzene;

DOI:10.1021/jo00350a069

upstream raw materials:

triphenylphosphine

7-azido-2-(2'-pyridyl)quinoline-5,8-quinone

2-acetylpyridine

methyl 4-bromo-2-nitro-3-hydroxybenzoate