N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

Base Information

Chemical Name:N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline
CAS No.:1416314-75-4
Molecular Formula:C₂₂H₁₇FN₄O₂
Molecular Weight:388.401
Hs Code.:

Synonyms:N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

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Chemical Property of N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

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Technology Process of N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

There total 4 articles about N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1416314-75-4
N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

1.2: 5 h / 75 °C / Inert atmosphere

1.3: 2 h / 55 °C / Inert atmosphere

2.1: iron(III) chloride hexahydrate / ethanol / Reflux

2.2: Reflux

3.1: potassium carbonate / acetone; water / 1 h / 5 °C

3.2: 13.33 h / 15 - 25 °C

With iron(III) chloride hexahydrate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/op500030v

Reference yield:

: 2739-97-1
pyridine-2-acetonitrile

: 1416314-75-4
N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; N,N-dimethyl acetamide / 3 h / Reflux

2.1: ethanol / 0.5 h / Reflux

2.2: 12 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

3.2: 5 h / 75 °C / Inert atmosphere

3.3: 2 h / 55 °C / Inert atmosphere

4.1: iron(III) chloride hexahydrate / ethanol / Reflux

4.2: Reflux

5.1: potassium carbonate / acetone; water / 1 h / 5 °C

5.2: 13.33 h / 15 - 25 °C

With iron(III) chloride hexahydrate; potassium carbonate; In ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/op500030v

Reference yield:

: 127350-92-9
(2-fluoro-4-nitrophenyl)hydrazine

: 1416314-75-4
N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / ethanol / 2 h / Reflux

2.1: ethanol; water / Reflux

2.2: 0.25 h / Reflux

3.1: potassium carbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane; water;