Technology Process of 4-((R)-1-((S)-1,1-dimethylethylsulfinamido)-4,4-dimethylpentyl)benzoate
There total 3 articles about 4-((R)-1-((S)-1,1-dimethylethylsulfinamido)-4,4-dimethylpentyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3-dimethylbutyl bromide;
With
magnesium;
iodine;
In
diethyl ether;
for 2.75h;
Inert atmosphere;
Reflux;
(S)-isopropyl 4-((tert-butylsulfinylimino)methyl)benzoate;
In
diethyl ether;
at -78 - 20 ℃;
for 2h;
With
ammonium chloride;
In
diethyl ether; water; ethyl acetate;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 64 h / 70 °C
2.1: caesium carbonate / dichloromethane / 30 h / 42 °C
3.1: magnesium / iodine / diethyl ether / 2.75 h / Inert atmosphere; Reflux
3.2: 2 h / -78 - 20 °C
3.3: 1 h / 0 - 20 °C
With
potassium carbonate; caesium carbonate; magnesium;
iodine;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / dichloromethane / 30 h / 42 °C
2.1: magnesium / iodine / diethyl ether / 2.75 h / Inert atmosphere; Reflux
2.2: 2 h / -78 - 20 °C
2.3: 1 h / 0 - 20 °C
With
caesium carbonate; magnesium;
iodine;
In
diethyl ether; dichloromethane;
