[2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Base Information

• Chemical Name: [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester
• CAS No.: 673485-36-4
• Molecular Formula: C₃₇H₅₄N₄O₁₄
• Molecular Weight: 778.854
• Mol file: 673485-36-4.mol

Synonyms:[2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Chemical Property of [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

There total 11 articles about [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (673485-36-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 87.8 percent / Et₃N; DMAP / ethyl acetate / 0.33 h / 20 °C

3: 97.4 percent / dimethylformamide / 0.17 h / 20 °C

4: 77.5 percent / Amberlyst 15 / methanol / 2 h / 20 °C

5: TFA

6: 119.1 mg / triethylamine / dimethylformamide / 0.25 h

With 1H-imidazole; dmap; Amberlyst 15; triethylamine; trifluoroacetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja039052p

Reference yield:

syringic alcohol (530-56-3) → [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (673485-36-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 52.8 percent / Et₃N / tetrahydrofuran / 1 h / 20 °C

2: 80.9 percent / dimethylformamide / 0.17 h / 20 °C

3: TFA

4: 169.4 mg / triethylamine / dimethylformamide / 0.25 h

5: 58.2 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

6: 119.1 mg / triethylamine / dimethylformamide / 0.25 h

With dmap; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja039052p

Reference yield:

methyl-(2-methylamino-ethyl)-carbamic acid 4-hydroxymethyl-2,6-dimethoxy-phenyl ester → [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (673485-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 169.4 mg / triethylamine / dimethylformamide / 0.25 h

2: 58.2 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

3: 119.1 mg / triethylamine / dimethylformamide / 0.25 h

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja039052p

upstream raw materials:

2,6-bis(hydroxymethyl)-4-methylphenol

syringic alcohol

2,6-bis(((tert-butyldimethylsilyl)oxy)methyl)-4-methylphenol

{2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester

Downstream raw materials:

C₅₁H₆₀N₆O₂₂